Uncoating is, in the most simple terms, the separation of the nucleic acid from the capsid. We think you have liked this presentation. Remember that the cell must also provide the machinery that the virus requires to replicate. OK Biology Sylvia S. May require a specific pH May require a specific ionic strength May require the presence of specific ions in the media. There are three main mechanisms of penetration by naked viruses: The Art of Reconstruction. The capsid penetration of virus complex moves along the microtubules to the nucleus and the genomic DNA enters the nucleus through penetration of virus pore uncoating. Registration Forgot your password? Sendai virus — Attachment occurs via the hemagglutinin-neuraminidase HN protein which has both the hemagglutinating and neuraminidase functions on the same protein.