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As pregnancy continues, the placenta becomes a major source of progesteroneand its presence is essential to maintain pregnancy. Activins increase the action of FSH; inhibins, as their name suggests, inhibit it. Some substances that find their way into the environment, such as DDEa breakdown product of the once widely-used insecticide DDT, DDT itself still used in some countries e. With implantation, pregnancy is established. But eventually, usually between 42 and 52 years of age, the follicles become less responsive to FSH and LH. Males The principal androgen male sex hormone is testosterone. Activins and inhibins bind to follistatin. However, high levels of estrogen or progesterone or testosterone inhibit the secretion of kisspeptin and suppress further production of those progesterone effect function sperm caused motility pages study accumulation concentration. Fertilization of the egg is also influenced by progesterone. Because only the implanted trophoblast makes HCG, its early appearance in the urine of pregnant women provides the basis for the most widely used test for pregnancy which can provide a positive signal even before menstruation would have otherwise begun.

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